Cartherics and TiCARos collaborate to lead advancement of CLIP-CAR technology

Cartherics has partnered with TiCARos to develop CLIP-CAR constructs that will be incorporated into Cartherics’ NK cells for evaluating their functionality in both in vitro and in vivo settings. TiCARos specializes in developing CAR-T cell products for the treatment of solid and blood cancers using its unique CLIP-CAR approach, which stabilizes the immune synapse between immune cells and tumor cells, resulting in improved efficacy.

According to Cartherics CEO, Professor Alan Trounson, this collaboration has the potential to enhance the effectiveness of cancer therapies by combining TiCARos’ CLIP-CAR technology with Cartherics’ allogeneic NK cell platform. By collaborating with innovative companies like TiCARos, Cartherics aims to build a leading portfolio of therapeutic products for cancer treatment. The two companies are working together on a CAR-NK product targeting tissue factor (TF) for triple negative breast cancer and other challenging cancers.

In this collaboration, each company has nominated a specific tumor antigen to target with CARs: Cartherics is focusing on TF while TiCARos is targeting CD19. The aim of this collaboration is to accelerate pipeline programs and expand the use of TiCARos’ technology beyond autologous cell therapies. If the research yields positive results, Cartherics and TiCARos will negotiate a development and commercialization agreement for their CAR-NK therapeutic approach.

By Riley Johnson

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